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LCZ696 CAS:936623-90-4

LCZ696 CAS:936623-90-4 CAS NO.936623-90-4

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Min.Order: 1 Metric Ton
Payment Terms: L/C,D/A,D/P,T/T,Other
Available Specifications:
Pharma Grade (1-100)Metric Ton1/Metric Ton1USDPharma Grade (1-1000)Metric Ton1/Metric Ton1USDPharma Grade (1-10)Metric Ton1/Metric Ton1USD

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LCZ696 CAS:936623-90-4
LCZ696
936623-90-4

Quick Details

ProName: LCZ696 CAS:936623-90-4
CasNo: 936623-90-4
Molecular Formula: C48H55N6Na3O8 / C48H55N6O8(-3)
Appearance: Odorless colorless liquid or solid
Application: Intermediate for pharmaceuticals
DeliveryTime: within 5-7 days after payment
PackAge: 25kg/ drum, or as your requirements
Port: Shanghai port
ProductionCapacity: 100 Metric Ton/Month
Purity: 99.9%min
Storage: regualr storage
Transportation: By air、ship and courier
LimitNum: 1 Metric Ton
Heavy metal: N/A
MW: 90.12
EINECS: 203-786-5
Boiling point: 230 °C(lit.)
Melting point: 20 °C
Brand: zhishang
density: 1.017 g/mL at 25 °C(lit.)
vapor density: 3.1 (vs air)
refractive index: n20/D 1.445(lit.)
Fp: 135 °C
storage temp.: 2-8°C
PH: 7-8 (500g/l, H2O, 20℃)
explosive limit: 1.95-18.3%(V)
Water Solubility: Miscible
Sensitive: Hygroscopic
BRN: 1633445
HS Code: 29053980
assay: 99.0% min

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Details

LCZ696

[Chemical Name]:	Valsartan/sacubitril; LCZ-696; LCZ 696
[Synonyms ]:	Entresto; L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5); trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate; trisodium 3-((1S,3R)-1-(biphenyl-4-ylmethyl)-3-(ethoxycarbonyl)butylcarbamoyl)propionate (S)-3-methyl-2-(pentanoyl-(2-(tetrazol-1-at-5-yl)biphenyl-4'-ylmethyl)amino)butyrate hemipentahydrate
[CAS No.]:	936623-90-4
[Structure Formula]:
[Molecular Formula]:	C48H55N6Na3O8 / C48H55N6O8(-3)
[Molecular Weight]:	843.99
[Solubility]:	in DMSO > 10 mM
[Purity ( Assay ) ]:	99.0% min
[Biological activity ]:	LCZ696 is a first-in-class dual inhibitor of the angiotensin II receptor(AT II receptor) and neprilysin; a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). IC50 value: Target: AT II receptor; neprilysin Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours) . LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms .
[Usage/Application]:	LCZ696 is used for the treatment of heart failure , LCZ696 is believed to be able to reduce the pressure of heart failure, and promote heart muscle ability
[Packing]:	In small aluminum foil bag or 1kg-10kg Tin