High Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0

High Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0 CAS NO.29908-03-0

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Product Details

Keywords

High Quality SAMe S-Adenosyl-L-Methionine / 29908-03-0
SAMe S-Adenosyl-L-Methionine
CAS 29908-03-0

Quick Details

ProName: High Quality SAMe S-Adenosyl-L-Methion...
CasNo: 29908-03-0
Molecular Formula: C15H24N6O5S
Appearance: WhitePowder
Application: pharmaceutical intermediates
DeliveryTime: within 5-7 days after payment
PackAge: 25kg/ drum, or as your requirements
Port: Shanghai port
ProductionCapacity: 100 Metric Ton/Month
Purity: 99%min
Storage: regualr storage
Transportation: By air、ship and courier
LimitNum: 1 Metric Ton
Related Substances: undetected
Residue on Ignition: less than 0.05%
Heavy Metal: less than 0.02%
Valid Period: 3 years
EINECS: 249-946-8
Application: Pharm Intermediates
Appearance: WhitePowder
Molecular Weight: 400.45
Melting point: 202-204°C
Brand: zhishang
Product name: S-Adenosyl-L-methionine
HPLC: available
NMR: available

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Details

High quality S-Adenosyl-L-methionine, S-Adenosyl methionine, 29908-03-0, C15H24N6O5S GMP manufacturers

S-Adenosyl methionine SAMe 29908-03-0 SAMe99%

SAMe (S-Adenosyl-L-methionine)

CAS no. 29908-03-0

Purity: 98% 99%

COA of Specification

Total content	≥98%
Ademetionine	50.0~53.0%
Identification
Chemical Reaction	Positive
IR	Conforms
Retention time of a major peak	Meet the requirements
Clarity of solution	≤reference solution Y1
Acid value	1.5~2.5
Sadenosyl-L-Homocystein (HPLC)	≤0.5
Methithioadenosine(HPLC)	≤1.0%
Adenine(HPLC)	≤0.5%
S.S isomer(HPLC)	≥62.0%
Butanedisufoinc acid	46.0~49.0%
Endotoxin	≤0.3EU/mg
Water content	≤3.0%
Residue on ignition	≤0.3%
Heavy metals	≤10ppm
Appearance	Almost white powder, very hygroscopic

Function:

1 S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

2 The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.

3 In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.

The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases (EC 2.1.1) that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAM, completing the cycle.

4 Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

5 SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

6 In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.