[product name] oleanolic acid

[English name] acid Oleanolic.
[name] (3) acid -3-Hydroxyolean-12-en-28-oic.
[molecular formula] C30H48O3
Molecular weight 456
[Mp] 306 ~308
Oleanol, Astrantigeninc, Caryophyllia, Giganteumgeninc.
[A S C] 508-02-1.
[EINECS] 208-081-6
 

1. To reduce the liver injury: oleanolic acid is a pentacyclic triterpenoid compound, on carbon tetrachloride induced rat acute chronic liver injury has obvious protective effect. After treatment, the swelling of the mitochondria and dilated rough endoplasmic reticulum was restored. It can also make the acute and chronic liver injury of the liver cells of the balloon like degeneration, necrosis and inflammatory response was significantly reduced. The accumulation of triglyceride in the liver decreased and the amount of glycogen increased.

2. To reduce the serum alanine aminotransferase activity: oleanolic acid on acute and chronic hepatitis and liver cirrhosis rats had significantly reduced enzyme.
3 decreased serum r- globulin, and was consistent with the histological observation of liver related inflammatory response.
4. To promote the regeneration of liver cells: oleanolic acid can induce the rat residual liver nuclear mitotic figures increased significantly and regenerative degree higher than that of the control group, suggesting that can promote cell regeneration.
5 to reduce the level of brain homogenate of liver cirrhosis rats: because of the obvious decrease of the level of brain homogenate, it can inhibit the generation of pseudo neurotransmitter, which is beneficial to the prevention and treatment of hepatic encephalopathy.
6. Inhibition of liver fibrosis: the oleanolic acid on liver fibrosis in rats, liver fibrosis and severe was significantly reduced and decreased hepatic collagen content, suggesting that has a role in the prevention and treatment of liver cirrhosis.
7. Oleanolic acid in mice mononuclear phagocytic cell, macrophage phagocytic function and experimental arthritis significantly inhibited, but the specific humoral immunity and antigen combined with cells. Enhanced immunity and inhibition of S180 tumor growth.
8 the protective effect of chromosome damage, preventive effect on experimental atherosclerosis, also can correct protein metabolism disorders.